[PDF] No Evidence for Circulating Retina Specific Autoreactive T-cells in Latent Tuberculosis-associated Uveitis and Sarcoid Uveitis | Semantic Scholar (2024)

This study is one of the first of its kind to look into MTB specific T cell activation marker profiling of peripheral blood in patients with ocular TB and found no significant difference between treatment responders and non-responders for the proportion of CD4 + T cells specific for PPD or ESAT-6+ CFP-10.

Tuberculosis infection can effectively induce autoimmune responses, contributing to increased expression of Th1 cells and associated cytokines, ultimately leading to immune dysregulation and is helpful for the clinical diagnosis and the development of targeted therapeutic drugs for this disease.

Existing diagnostic approaches and recently discovered biomarkers that may contribute to establishing OTB diagnosis, choice of anti-tubercular therapy (ATT) regimen, and treatment monitoring are summarized.

180 vitreous proteins are investigated to discover novel biomarkers and broaden disease insights by comparing primary vitreoretinal lymphoma ((P)VRL) versus other aetiologies and sarcoid uveitis versus tuberculosis (TB)‐associated uveitas.

Autoreactive T cells are present in TBU eyes and are relatively resistant to AICD, and an understanding of this epiphenomenon could be crucial in planning treatment of TBU patients, and interpreting response to anti-TB therapy.

The data demonstrate that PBMCs exhibit an IL-17-mediated immune response to retina lysate in patients with active disease naïve to systemic therapy and provide evidence that links the Th17 signatures to ocular-specific immune responses in BSCR.

Aqueous cytokine and chemokine analyses suggest that subjects with uveitis associated with TB who respond to anti-TB therapy do not have an active ocular tuberculous infection, but rather an autoimmune-related ocular inflammation that may be triggered by TB.

Although antibodies to retinal α-enolase, recoverin and other RAs are present mainly or exclusively in lung cancer sera, none of them seems to be a specific marker of a particular disease.

The results indicate that there are specific immunodominant determinants to human S-Ag in patients with certain forms of uveitis, however, in individual patients, response is not limited to these determinants.

RPE cells robustly controlled intracellular outgrowth of Mtb early after infection and might reflect a balance between mechanisms aimed at Mtb eradication and mechanisms that limit retinal inflammation.

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