[PDF] Prevalence Of Positive Quantiferon-Tb Gold In-Tube Test In Uveitis And Its Clinical Implications In A Country Non-Endemic For Tuberculosis. | Semantic Scholar (2024)

The significant proportion of QFT-positive patients in this large series of sarcoid uveitis patients makes us suggest not to exclude the diagnosis of Sarcoidosis in case of positive QFT in a low-endemic country for tuberculosis, and to manage these patients early by initiating without delay systemic steroids associated with latent tuberculosis therapy.

A QuantiFERON test value of >2 IU/mL was associated with a greater chance of responding to ATT and the optimal threshold to maximise both Sp and SE for diagnosis of TB uveitis was 4IU/mL.

How intraocular inflammation in ocular TB is not merely an immunologic response to bacilli, but an active tuberculosis infection is discussed, to arrive at the diagnosis of this infectious uveitis entity.

An understanding of pathogenic mechanisms, and its correlation with clinical and imaging features, can facilitate early recognition of microbial factors and institution of appropriate therapy.

Q FT-G-positive patients frequently had uveitis of unknown cause and exhibited clinical features of occlusive retinal vasculitis, commonly associated with high QFT-G levels, young age, and male gender.

The study shows that the QFT-G test is very useful in the diagnosis and management of suspected ocular TB and was found to be very sensitive in identifying latent TB patients who, upon treatment, had a significantly reduced frequency of recurrences.

QFT testing gives surprisingly high numbers of positives in uveitis patients and is not sufficiently explained by immigrant status of the patients, which raises important questions regarding treatment implications.

To clarify interferon-gamma release assay (IGRA) contributions to intraocular tuberculosis management, according to related TB endemic prevalence, distinct guidelines should be determined for managing patients with suspected ocular TB, first taking into consideration the relative TB prevalence.

Data from COTS-1 suggest that PCR is not commonly done for diagnosing intraocular TB and positive/negative results may not influence management or treatment outcomes in the real world scenario.

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